Recombinant Human NECTIN3 protein, Fc-tagged
Cat.No. : | NECTIN3-0634H |
Product Overview : | Human Nectin-3 / CD113 Protein, Fc Tag, Gly 58 - Asp 400 (Accession # Q9NQS3) was produced in human 293 cells (HEK293). |
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Description : | Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Gly 58 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5, 10% trehalose. |
Molecular Mass : | Human Nectin-3, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 64.3 kDa. The reducing (R) protein migrates as 80-100 kDa in SDS-PAGE due to glycosylation. |
Protein length : | Gly 58 - Asp 400 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Shipping : | Powder,RT |
Gene Name : | NECTIN3 nectin cell adhesion molecule 3 [ Homo sapiens (human) ] |
Official Symbol : | NECTIN3 |
Synonyms : | PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3; nectin 3; poliovirus receptor-related 3; poliovirus receptor-related protein 3; nectin-3 |
Gene ID : | 25945 |
mRNA Refseq : | NM_001243286.1 |
Protein Refseq : | NP_001230215.1 |
UniProt ID : | Q9NQS3 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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