Recombinant Human NEDD4L Protein (A2-D975), Tag Free

• Cat.No.: NEDD4L-0438H
• Product Overview: Recombinant Human (GG)-NEDD4L(A2-D975 end) Protein was expressed in E. coli.

Specification

• Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Plays a role in dendrite formation by melanocytes. Involved in the regulation of TOR signaling. Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF.
• Source: E. coli
• Species: Human
• Tag: No tag
• Form: Liquid
• Protein Length: A2-D975
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [ Homo sapiens (human) ]
• Official Symbol: NEDD4L
• Synonyms: NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down regulated 4 like; E3 ubiquitin-protein ligase NEDD4-like; KIAA0439; NEDD4 2; RSP5; ubiquitin-protein ligase Rsp5; NEDD4-2; NEDD4.2; hNEDD4-2; FLJ33870
• Gene ID: 23327
• mRNA Refseq: NM_001144964
• Protein Refseq: NP_001138436
• MIM: 606384
• UniProt ID: Q96PU5