Recombinant Human Neurotrophin 3 NTF3-22H

Recombinant Human Neurotrophin 3

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Cat.No. : NTF3-22H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human Neurotrophin 3 encoding the NT-3 prepropeptide was inserted into a baculovirus expression vector and expressed inSf 21insect cells.
Description : Neurotrophin 3 (NT-3), also known as NTF3 is a basic protein found in neurons of the central nervous system. NT-3 selectively supports the survival of neuronal cell populations. It rapidly potentiate the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture and thus appears to be involved in the regulation of functions of developing synapses. NT-3 negatively modulates nerve growth factor (NGF) receptor expression and associated nociceptive phenotype in intact neurons, suggesting a beneficial role in treating aspects of neuropathic pain mediated by NGF. NT-3 is effective at suppressing thermal hyperalgesia associated with chronic constriction injury (CCI).
Molecular Weight : The predicted molecular weight of Recombinant Human NT-3 is Mr 13.6 kDa.
Source : Sf 21 Insect Cells.
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human NT-3 was determined by its ability to stimulate proliferation of the TrkB-transfected cell line, BaF-TrkB-BD. The expected ED50 for this effect is typically 10 - 30 ng/mL.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1b8k. :

Gene Name : NTF3 neurotrophin 3 [ Homo sapiens ]
Synonyms : NTF3; neurotrophin 3; HDNF; NGF2; NGF-2; MGC129711; NT3; NT-3; Nerve growth factor 2; Neurotrophic factor
Gene ID : 4908
mRNA Refseq : NM_001102654
Protein Refseq : NP_001096124
MIM : 162660
UniProt ID : P20783
Chromosome Location : 12p13
Pathway : Neurotrophin signaling pathway; MAPK signaling pathway
Function : growth factor activity; nerve growth factor binding; neurotrophin receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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