Recombinant Human NFATC1, GST-tagged

• Cat.No.: NFATC1-7051H
• Product Overview: Recombinant full-length human NFATC1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development. NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~125 kDa
• Protein length: Full length
• Purity: >85%
• Applications: Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.2 μg/μl

Gene Information

• Gene Name: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens ]
• Official Symbol: NFATC1
• Synonyms: NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic 1; NF ATC; NFAT2; NFATc; NF-ATc1; NFAT transcription complex cytosolic component; NF-ATC; MGC138448
• Gene ID: 4772
• mRNA Refseq: NM_006162
• Protein Refseq: NP_006153
• MIM: 600489
• UniProt ID: O95644
• Chromosome Location: 18q23
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
• Function: DNA binding; FK506 binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II transcription factor binding; mitogen-activated protein kinase p38 binding; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription regulatory region DNA binding