Recombinant Human NLRP1 protein, MYC/DDK-tagged

• Cat.No.: NLRP1-3804H
• Product Overview: Recombinant Human NLRP1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 165.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Publications:
  • A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases (2022)

Gene Information

• Gene Name: NLRP1 NLR family, pyrin domain containing 1 [ Homo sapiens ]
• Official Symbol: NLRP1
• Synonyms: NLRP1; NLR family, pyrin domain containing 1; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 , NALP1; NACHT, LRR and PYD domains-containing protein 1; CARD7; CLR17.1; DEFCAP; DKFZp586O1822; KIAA0926; NAC; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 1; caspase recruitment domain protein 7; NACHT, LRR and PYD containing protein 1; NACHT, leucine rich repeat and PYD containing 1; caspase recruitment domain-containing protein 7; nucleotide-binding domain and caspase recruitment domain; death effector filament-forming Ced-4-like apoptosis protein; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; NALP1; SLEV1; PP1044; VAMAS1; DEFCAP-L/S
• Gene ID: 22861
• mRNA Refseq: NM_033004
• Protein Refseq: NP_127497
• MIM: 606636
• UniProt ID: Q9C000
• Chromosome Location: 17p13
• Pathway: Cellular roles of Anthrax toxin, organism-specific biosystem; Immune System, organism-specific biosystem; Inflammasomes, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD-like receptor signaling pathway, organism-specific biosystem; NOD-like receptor signaling pathway, conserved biosystem; Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem
• Function: ATP binding; cysteine-type endopeptidase activator activity involved in apoptotic process; enzyme binding; nucleotide binding; protein binding; protein domain specific binding