| Description : |
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75 kDa |
| AA Sequence : |
MAMAKARKPREALLWALSDLEENDF KKLKFYLRDMTLSEGQPPLARGELE GLIPVDLAELLISKYGEKEAVKVVL KGLKVMNLLELVDQLSHICLHDYRE VYREHVRCLEEWQEAGVNGRYNQVL LVAKPSSESPESLACPFPEQELESV TVEALFDSGEKPSLAPSLVVLQGSA GTGKTTLARKMVLDWATGTLYPGRF DYVFYVSCKEVVLLLESKLEQLLFW CCGDNQAPVTEILRQPERLLFILDG FDELQRPFEEKLKKRGLSPKESLLH LLIRRHTLPTCSLLITTRPLALRNL EPLLKQARHVHILGFSEEERARYFS SYFTDEKQADRAFDIVQKNDILYKA CQVPGICWVVCSWLQGQMERGKVVL ETPRNSTDIFMAYVSTFLPPDDDGG CSELSRHRVLRSLCSLAAEGIQHQR FLFEEAELRKHNLDGPRLAAFLSSN DYQLGLAIKKFYSFRHISFQDFFHA MSYLVKEDQSRLGKESRREVQRLLE VKEQEGNDEMTLTMQFLLDISKKDS FSNLELKFCFRISPCLAQDLKHFKE QMESMKHNRTWDLEFSLYEAKIKNL VKGIQMNNVSFKIKHSNEKKSQSQN LFSVKSSLSHGPKEEQKCPSVHGQK EGKDNIAGTQKEASTGKGRGTEETP KNTYITRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
