Recombinant Human NLRP2 Protein, GST-tagged

• Cat.No.: NLRP2-5921H
• Product Overview: Human NLRP2 full-length ORF ( AAH39269, 1 a.a. - 846 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 118.8 kDa
• AA Sequence: MVSSAQMGFNLQALLEQLSQDELSK FKYLITTFSLAHELQKIPHKEVDKA DGKQLVEVLTTHCDSYWVEMASLQV FEKMHRMDLSERAKDEVREAALKSF NKRKPLSLGITRKERPPLDVDEMLE RFKTEAQAFTETKGNVICLGKEVFK GKKPDKDNRCRYILKTKFREMWKSW PGDSKEVQVMAERYKMLIPFSNPRV LPGPFSYTVVLYGPAGLGKTTLAQK LMLDWAEDNLIHKFKYAFYLSCREL SRLGPCSFAELVFRDWPELQDDIPH ILAQARKILFVIDGFDELGAAPGAL IEDICGDWEKKKPVPVLLGSLLNRV MLPKAALLVTTRPRALRDLRILAEE PIYIRVEGFLEEDRRAYFLRHFGDE DQAMRAFELMRSNAALFQLGSAPAV CWIVCTTLKLQMEKGEDPVPTCLTR TGLFLRFLCSRFPQGAQLRGALRTL SLLAAQGLWAQTSVLHREDLERLGV QESDLRLFLDGDILRQDRVSKGCYS FIHLSFQQFLTALFYTLEKEEEEDR DGHTWDIGDVQKLLSGVERLRNPDL IQAGYYSFGLANEKRAKELEATFGC RMSPDIKQELLRCDISCKGGHSTVT DLQELLGCLYESQEEELVKEVMAQF KEISLHLNAVDVVPSSFCVKHCRNL QKMSLQVIKENLPENVTASESDAEV ERSQDDQHMLPFWTDLCSIFGSNKD LMGLAINDSFLSASLVRILCEQIAS DTCHLQRVVFKNISPADAHRNLCLA LRGHKTVTYLTLQGNDQDDMFPALC EVLRHPECNLRYLGLVSCSATTQQW ADLSLALEVNQSLTCVNLSDNELLD EGAKLLYTTLRHPKCFLQRLS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NLRP2 NLR family, pyrin domain containing 2 [ Homo sapiens ]
• Official Symbol: NLRP2
• Synonyms: NLRP2; NLR family, pyrin domain containing 2; NACHT, leucine rich repeat and PYD containing 2 , NALP2; NACHT, LRR and PYD domains-containing protein 2; CLR19.9; FLJ20510; NBS1; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domain containing 2; PAN1; PYPAF2; nucleotide-binding site protein 1; PYRIN-containing APAF1-like protein 2; NACHT, LRR and PYD containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; NALP2
• Gene ID: 55655
• mRNA Refseq: NM_001174081
• Protein Refseq: NP_001167552
• MIM: 609364
• UniProt ID: Q9NX02