"NLRP2" Related Products


Recombinant Human NLRP2 Protein, MYC/DDK-tagged

Cat.No. : NLRP2-36H
Product Overview : Recombinant protein of human NLR family, pyrin domain containing 2 (NLRP2) with C-MYC/DDK tag was expressed in HEK293T.
Description : This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Molecular Mass : 120.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage : Store at –80 centigrade. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : NLRP2
Official Symbol : NLRP2 NLR family pyrin domain containing 2 [ Homo sapiens (human) ]
Synonyms : NLRP2; NLR family pyrin domain containing 2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9; NACHT, LRR and PYD domains-containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; nucleotide-binding site protein 1
Gene ID : 55655
mRNA Refseq : NM_017852
Protein Refseq : NP_060322
MIM : 609364
UniProt ID : Q9NX02

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