Recombinant Human NMNAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: NMNAT1-6280H
• Product Overview: NMNAT1 MS Standard C13 and N15-labeled recombinant protein (NP_073624) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 31.9 kDa
• AA Sequence: MENSEKTEVVLLACGSFNPITNMHL RLFELAKDYMNGTGRYTVVKGIISP VGDAYKKKGLIPAYHRVIMAELATK NSKWVEVDTWESLQKEWKETLKVLR HHQEKLEASDCDHQQNSPTLERPGR KRKWTETQDSSQKKSLEPKTKAVPK VKLLCGADLLESFAVPNLWKSEDIT QIVANYGLICVTRAGNDAQKFIYES DVLWKHRSNIHVVNEWIANDISSTK IRRALRRGQSIRYLVPDLVQEYIEK HNLYSSESEDRNAGVILAPLQRNTA EAKTTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: NMNAT1 nicotinamide nucleotide adenylyltransferase 1 [ Homo sapiens (human) ]
• Official Symbol: NMNAT1
• Synonyms: NMNAT1; nicotinamide nucleotide adenylyltransferase 1; nicotinamide nucleotide adenylyltransferase; nicotinamide mononucleotide adenylyltransferase 1; NMNAT; PNAT1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1
• Gene ID: 64802
• mRNA Refseq: NM_022787
• Protein Refseq: NP_073624
• MIM: 608700
• UniProt ID: Q9HAN9