Recombinant Human NPHS1 protein, His & T7-tagged
Cat.No. : | NPHS1-5640H |
Product Overview : | Recombinant Human NPHS1 aa. (His705~Ser1055 (Accession # O60500)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. |
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 41.7kDa |
Protein length : | His705~Ser1055 (Accession # O60500) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >90% |
Characteristic : | The isoelectric point is 5.7. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | NPHS1 NPHS1, nephrin [ Homo sapiens (human) ] |
Official Symbol : | NPHS1 |
Synonyms : | NPHS1; NPHS1, nephrin; CNF; NPHN; nephrin; nephrosis 1, congenital, Finnish type (nephrin); renal glomerulus-specific cell adhesion receptor; truncated NPHS1 |
Gene ID : | 4868 |
mRNA Refseq : | NM_004646.3 |
Protein Refseq : | NP_004637.1 |
UniProt ID : | O60500 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMutations in the NPHS1 gene cause a decrease in nephrin protein and abnormal distribution.
NPHS1 expression is downregulated in diabetic nephropathy tissues.
LPS silences NPHS1 gene expression through histone H3K9 dimethylation.
Expression of lncRNA CRNDE negative correlation with NPHS1.
NPHS1 is closely associated with the study of multiple kidney diseases.
Customer Reviews (3)
Write a reviewProfessional personnel to provide after-sales service, experimental results are guaranteed.
High protein concentration, good quality, worth buying.
The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.
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