Recombinant Human NRG2 Protein, His-tagged

• Cat.No.: NRG2-363H
• Product Overview: Recombinant Human NRG2(Phe101~Phe211) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 13.6kDa
• Protein length: Phe101~Phe211
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others
• Publication:
  Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling (2021)
  Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells (2021)

Gene Information

• Gene Name: NRG2 neuregulin 2 [ Homo sapiens ]
• Official Symbol: NRG2
• Synonyms: NRG2; neuregulin 2; pro-neuregulin-2, membrane-bound isoform; divergent of neuregulin 1; Don 1; HRG2; neural and thymus derived activator for ErbB kinases; NTAK; pro-NRG2; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; DON1
• Gene ID: 9542
• mRNA Refseq: NM_001184935
• Protein Refseq: NP_001171864
• MIM: 603818
• UniProt ID: O14511