Recombinant Human NSD3 Protein, GST tagged

• Cat.No.: NSD3-16H
• Product Overview: Recombinant human WHSC1L1 (NSD3) (1038-end) was expressed by baculovirus in Sf9 insect cells using an N terminal GST tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1038-end
• Description: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described.
• Molecular Mass: 72 kDa
• Purity: > 90%
• Stability: 1 yr at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Concentration: 0.2 μg/μL
• Shipping: Dry Ice
• Reference: 1. Kim SM, et al: Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity. Biochem Biophys Res Commun. 2006 Jun 23;345(1):318-23. 2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.

Gene Information

• Gene Name: NSD3 nuclear receptor binding SET domain protein 3 [ Homo sapiens (human) ]
• Official Symbol: NSD3
• Synonyms: NSD3; nuclear receptor binding SET domain protein 3; KMT3F; KMT3G; WHISTLE; WHSC1L1; pp14328; histone-lysine N-methyltransferase NSD3; Wolf-Hirschhorn syndrome candidate 1-like 1; nuclear SET domain-containing protein 3; protein whistle; EC 2.1.1.370; EC 2.1.1.371
• Gene ID: 54904
• mRNA Refseq: NM_017778
• Protein Refseq: NP_060248
• MIM: 607083
• UniProt ID: Q9BZ95