"OSCAR" Related Products

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Recombinant Human OSCAR Protein, Fc-tagged

Cat.No. : OSCAR-22H
Product Overview : Recombinant human OSCAR (Asp19-Asn229) protein fused with Fc region of human IgG1 (Pro100-Lys330) at C-terminus was expressed in mouse myeloma cell line.
Description : Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : NS0
Species : Human
Tag : Fc
Form : Disulfide-linked homodimer
Bio-activity : Measured by its binding ability in a functional ELISA. When Bovine Collagen I is coated at 10 µg/mL, Recombinant Human OSCAR Fc Chimera binds with an ED50 of 1-8 ng/mL.
Molecular Mass : 50 kDa
N-terminal Sequence Analysis : Asp19
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Storage : 12 months from date of receipt, ≤ -20 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Preservative : Reconstitute at 500 μg/mL in PBS.
Gene Name : OSCAR osteoclast associated, immunoglobulin-like receptor [ Homo sapiens (human) ]
Official Symbol : OSCAR
Synonyms : hOSCAR; MGC33613; OSCAR; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; osteoclast associated, immunoglobulin-like receptor; osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIGR3; PIgR-3; Poly-Ig receptor 3; Polymeric immunoglobulin receptor 3
Gene ID : 126014
mRNA Refseq : NM_133169
Protein Refseq : NP_573399
MIM : 606862
UniProt ID : Q8IYS5

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