Active Recombinant Human OSCAR Protein, Fc-tagged

• Cat.No.: OSCAR-22H
• Product Overview: Recombinant human OSCAR (Asp19-Asn229) protein fused with Fc region of human IgG1 (Pro100-Lys330) at C-terminus was expressed in mouse myeloma cell line.

Specification

• Description: Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Fc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. When Bovine Collagen I is coated at 10 µg/mL, Recombinant Human OSCAR Fc Chimera binds with an ED50 of 1-8 ng/mL.
• Molecular Mass: 50 kDa
• N-terminal Sequence Analysis: Asp19
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: 12 months from date of receipt, ≤ -20 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Preservative: Reconstitute at 500 μg/mL in PBS.

Gene Information

• Gene Name: OSCAR osteoclast associated, immunoglobulin-like receptor [ Homo sapiens (human) ]
• Official Symbol: OSCAR
• Synonyms: hOSCAR; MGC33613; OSCAR; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; osteoclast associated, immunoglobulin-like receptor; osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIGR3; PIgR-3; Poly-Ig receptor 3; Polymeric immunoglobulin receptor 3
• Gene ID: 126014
• mRNA Refseq: NM_133169
• Protein Refseq: NP_573399
• MIM: 606862
• UniProt ID: Q8IYS5