Recombinant Human IFNGR1 Protein, His-tagged

• Cat.No.: OSCAR-001H
• Product Overview: Recombinant human OSCAR(19-282aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: OSCAR, also known as osteoclast-associated immunoglobulin-like receptor isoform 6, is an activating receptor expressed by human myeloid cells. It is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. It is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Its expression is detected specifically in preosteoclasts or mature osteoclasts. It is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Molecular Mass: 29.2 kDa
• AASequence: DITPSVPPASYHPKPWLGAQPATVV TPGVNVTLRCRAPQPAWRFGLFKPG EIAPLLFRDVSSELAEFFLEEVTPA QGGSYRCCYRRPDWGPGVWSQPSDV LELLVTEELPRPSLVALPGPVVGPG ANVSLRCAGRLRNMSFVLYREGVAA PLQYRHSAQPWADFTLLGARAPGTY SCYYHTPSAPYVLSQRSEVLVISWE GEGPEARPASSAPGMQAPGPPPSDP GAQAPSLSSFRPRGLVLQPLLPQTQ DSWDPAPPPSDPGVHHHHHH
• N-terminal Sequence Analysis: Asp 19
• Endotoxin: < 1.0 EU per 1 μg of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/mL (determined by Absorbance at 280nm)
• Storage Buffer: In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Warning: For research use only. This product is not intended or approved for human, diagnostics or veterin

Gene Information

• Gene Name: OSCAR osteoclast associated, immunoglobulin-like receptor [ Homo sapiens (human) ]
• Official Symbol: OSCAR
• Synonyms: OSCAR; osteoclast associated, immunoglobulin-like receptor; PIGR3; PIgR-3; osteoclast-associated immunoglobulin-like receptor; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; poly-Ig receptor 3; polymeric immunoglobulin receptor 3
• Gene ID: 126014
• mRNA Refseq: NM_001282349
• Protein Refseq: NP_001269278
• MIM: 606862
• UniProt ID: Q8IYS5