| Description : |
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
60.7 kDa |
| AA Sequence : |
MGKWRPRGCCRGNMQCRQEVPATLT SSELFSTRNQPQPQPQPLLADAPVP WAVASRMCLTPGQGCGHQGQDEGPL PAPSPPPAMSSSRKDHLGASSSEPL PVIIVGNGPSGICLSYLLSGYTPYT KPDAIHPHPLLQRKLTEAPGVSILD QDLDYLSEGLEGRSQSPVALLFDAL LRPDTDFGGNMKSVLTWKHRKEHAI PHVVLGRNLPGGAWHSIEGSMVILS QGQWMGLPDLEVKDWMQKKRRGLRN SRATAGDIAHYYRDYVVKKGLGHNF VSGAVVTAVEWGTPDPSSCGAQDSS PLFQVSGFLTRNQAQQPFSLWARNV VLATGTFDSPARLGIPGEALPFIHH ELSALEAATRVGAVTPASDPVLIIG AGLSAADAVLYARHYNIPVIHAFRR AVDDPGLVFNQLPKMLYPEYHKVHQ MMREQSILSPSPYEGYRSLPRHQLL CFKEDCQAVFQDLEGVEKVFGVSLV LVLIGSHPDLSFLPGAGADFAVDPD QPLSAKRNPIDVDPFTYQSTRQEGL YAMGPLAGDNFVRFVQGGALAVASS LLRKETRKPPTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
