| Description : |
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
64.1 kDa |
| AA Sequence : |
MFGKRKKRVEISAPSNFEHRVHTGF DQHEQKFTGLPRQWQSLIEESARRP KPLVDPACITSIQPGAPKTIVRGSK GAKDGALTLLLDEFENMSVTRSNSL RRDSPPPPARARQENGMPEEPATTA RGGPGKAGSRGRFAGHSEAGGGSGD RRRAGPEKRPKSSREGSGGPQESSR DKRPLSGPDVGTPQPAGLASGAKLA AGRPFNTYPRADTDHPSRGAQGEPH DVAPNGPSAGGLAIPQSSSSSSRPP TRARGAPSPGVLGPHASEPQLAPPA CTPAAPAVPGPPGPRSPQREPQRVS HEQFRAALQLVVDPGDPRSYLDNFI KIGEGSTGIVCIATVRSSGKLVAVK KMDLRKQQRRELLFNEVVIMRDYQH ENVVEMYNSYLVGDELWVVMEFLEG GALTDIVTHTRMNEEQIAAVCLAVL QALSVLHAQGVIHRDIKSDSILLTH DGRVKLSDFGFCAQVSKEVPRRKSL VGTPYWMAPELISRLPYGPEVDIWS LGIMVIEMVDGEPPYFNEPPLKAMK MIRDNLPPRLKNLHKVSPSLKGFLD RLLVRDPAQRATAAELLKHPFLAKA GPPASIVPLMRQNRTRTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
