Recombinant Human PASK Protein (S949-S1323), GST tagged

• Cat.No.: PASK-1119H
• Product Overview: Recombinant Human GST-TEV-PASK (S949-S1323 end) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: S949-S1323
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: PASK PAS domain containing serine/threonine kinase [ Homo sapiens (human) ]
• Official Symbol: PASK
• Synonyms: PASK; PAS domain containing serine/threonine kinase; PAS domain-containing serine/threonine-protein kinase; KIAA0135; PASKIN; STK37; per-arnt-sim (PAS) domain kinase; DKFZp434O051; DKFZp686P2031
• Gene ID: 23178
• mRNA Refseq: NM_001252119
• Protein Refseq: NP_001239048
• MIM: 607505
• UniProt ID: Q96RG2