| Description : |
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
37.5 kDa |
| AA Sequence : |
MDAGVTESGLNVTLTIRLLMHGKEV GSIIGKKGESVKRIREESGARINIS EGNCPERIITLTGPTNAIFKAFAMI IDKLEEDINSSMTNSTAASRPPVTL RLVVPATQCGSLIGKGGCKIKEIRE STGAQVQVAGDMLPNSTERAITIAG VPQSVTECVKQICLVMLETLSQSPQ GRVMTIPYQPMPASSPVICAGGQDR CSDAAGYPHATHDLEGPPLDAYSIQ GQHTISPLDLAKLNQVARQQSHFAM MHGGTGFAGIDSSSPEVKGYWASLD ASTQTTHELTIPNNLIGCIIGRQGA NINEIRQMSGAQIKIANPVEGSSGR QVTITGSAASISLAQYLINARLSSE KGMGCSTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
