Recombinant Human PCSK9 Protein, His-tagged PCSK9-041H

Recombinant Human PCSK9 Protein, His-tagged


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Cat.No. : PCSK9-041H Optional Service: Optional requirements on this protein
Product Overview : Active recombinant N-terminal His-tagged full length human PCSK9 protein (1-692) was expressed in HEK293 cells. Conjugated to DyLight™ 488.
Description : This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized
Bio-activity : PCSK9 downregulates LDL uptake.
Molecular Mass : 13.8 kDa prodomain + 59 kDa mature form
Protein length : 1-692
Purity : ≥90% as determined by SDS-PAGE
Stability : ≥ 9 months
Storage : At -80 centigrade.
Storage Buffer : PBS, pH 7.4, with 30% sucrose
PCSK9-DyLight™ 488 SDS-PAGE analysis :

Lane 1: MW Markers
Lane 2: PCSK9-DyLight™ 488 (2 μg)
Lane 3: PCSK9-DyLight™ 488 (4 μg)
The observed MW of these bands is slightly higher due to post-translational modifications.

PCSK9 is taken up by hepatocytes, downregulating LDL uptake. :

Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens (human) ]
Official Symbol : PCSK9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; subtilisin/kexin-like protease PC9
Gene ID : 255738
mRNA Refseq : NM_174936
Protein Refseq : NP_777596
MIM : 607786
UniProt ID : Q8NBP7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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