Recombinant Human PDCD1 Protein, Fc-tagged, Alexa Fluor 488 conjugated
Cat.No. : | PDCD1-188HAF488 |
Product Overview : | The Alexa Fluor 488 conjugatedextracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1. |
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Description : | CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. |
Source : | CHO |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Purity : | ≥98 % by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Stability : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Storage : | Short Term Storage: +4 centigrade; Long Term Storage: -20 centigrade. Avoid freeze/thaw cycles. |
Storage Buffer : | Lyophilized from 0.2 μm filtered solution in PBS. |
Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens ] |
Official Symbol : | PDCD1 |
Synonyms : | PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l; |
Gene ID : | 5133 |
mRNA Refseq : | NM_005018 |
Protein Refseq : | NP_005009 |
MIM : | 600244 |
UniProt ID : | Q15116 |
Products Types
◆ Recombinant Protein | ||
PDCD1-266H | Recombinant Human PDCD1 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
PDCD1-267H | Recombinant Human PDCD1 Protein (ECD), His-tagged(C-ter) | +Inquiry |
Pdcd1-4729M | Recombinant Mouse Pdcd1 Protein, DDK/His-tagged | +Inquiry |
PDCD1-260H | Active Recombinant Human PDCD1 Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
PDCD1-1173H | Recombinant Human PDCD1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PDCD1-2628MCL | Recombinant Mouse PDCD1 cell lysate | +Inquiry |
PDCD1-2873HCL | Recombinant Human PDCD1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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