| Description : |
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Tag Free |
| Protein length : |
PRO21-GLN167, ECD |
| Conjugation/Label : |
Biotin |
| Form : |
Lyophilised |
| Endotoxin : |
Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg). |
| Notes : |
FOR RESEARCH USE ONLY (RUO). |
| Storage : |
Recombinant PD-1 can be stored in working aliquots at 2 to 8 centigrade for one month, or at -20 to -70 centigrade for 1 year. It is recommended to add 0.1% HSA or BSA for long term storage. Avoid repeated freeze/thaw cycles. |
| Storage Buffer : |
Lyophilised from 0.2 μm filtered PBS solution, pH 7.2, 5% Trehalose. |
| Reconstitution : |
Upon receipt a quick spin of the vial followed by reconstitution in sterile PBS pH 7.4 to a concentration not less than 0.2 mg/mL. Solubilize for 1hr at room temp with gentle mixing. |
