Recombinant Human PDE3A Protein, His/GST-tagged
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Cat.No. : | PDE3A-01H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human PDE3A protein (669-1141) with a N-teminus His/GST-tag was expressed in insect cells. |
Description : | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | Insect cell |
Species : | Human |
Tag : | His/GST |
Form : | Lyophilized from sterile 20 mM Tris, pH 7.4, with 500 mM sodium chloride and 10% glycol, 3 mM DTT |
Molecular Mass : | 81.7 kDa |
Protein length : | 669-1141 |
Endotoxin : | <1.0 EU/μg, determined by the LAL endotoxin assay |
Purity : | ≥90% estimated by SDS-PAGE |
Stability : | ≥ 1 year |
Storage : | Store at -80 centigrade |
SDS-PAGE Analysis of PDE3A : |
![]() Lane 1: MW Markers, Lane 2: PDE3A, SDS-PAGE Analysis of PDE3A. This protein consists of 710 amino acids and has a calculated molecular weight of 81.7 kDa. By SDS-PAGE, under reducing conditions, the molecular mass of the protein is 93 kDa due to apparent post translational modifications. |
Gene Name : | PDE3A phosphodiesterase 3A [ Homo sapiens (human) ] |
Official Symbol : | PDE3A |
Synonyms : | PDE3A; phosphodiesterase 3A; HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; cyclic GMP-inhibited phosphodiesterase A; phosphodiesterase 3A, cGMP-inhibited |
Gene ID : | 5139 |
mRNA Refseq : | NM_000921 |
Protein Refseq : | NP_000912 |
MIM : | 123805 |
UniProt ID : | Q14432 |
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◆ Lysates
PDE3A-001HCL | Recombinant Human PDE3A cell lysate | +Inquiry |
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◆ Assay kits
Kit-1834 | PDE3A Assay Kit | +Inquiry |
Kit-1835 | PDE3A TR-FRET Assay Kit | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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