Recombinant Human PDE3A Protein, His/GST-tagged PDE3A-01H

Recombinant Human PDE3A Protein, His/GST-tagged

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Recombinant Human PDE3A Protein, His/GST-tagged

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Cat.No. : PDE3A-01H
Product Overview : Recombinant human PDE3A protein (669-1141) with a N-teminus His/GST-tag was expressed in insect cells.
Description : This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Source : Insect cell
Species : Human
Tag : His/GST
Form : Lyophilized from sterile 20 mM Tris, pH 7.4, with 500 mM sodium chloride and 10% glycol, 3 mM DTT
Molecular Mass : 81.7 kDa
Protein length : 669-1141
Endotoxin : <1.0 EU/μg, determined by the LAL endotoxin assay
Purity : ≥90% estimated by SDS-PAGE
Stability : ≥ 1 year
Storage : Store at -80 centigrade
SDS-PAGE Analysis of PDE3A :

Lane 1: MW Markers, Lane 2: PDE3A, SDS-PAGE Analysis of PDE3A. This protein consists of 710 amino acids and has a calculated molecular weight of 81.7 kDa. By SDS-PAGE, under reducing conditions, the molecular mass of the protein is 93 kDa due to apparent post translational modifications.

Gene Name : PDE3A phosphodiesterase 3A [ Homo sapiens (human) ]
Official Symbol : PDE3A
Synonyms : PDE3A; phosphodiesterase 3A; HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; cyclic GMP-inhibited phosphodiesterase A; phosphodiesterase 3A, cGMP-inhibited
Gene ID : 5139
mRNA Refseq : NM_000921
Protein Refseq : NP_000912
MIM : 123805
UniProt ID : Q14432

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