Recombinant Human PDE6A, GST-tagged PDE6A-1613H

Recombinant Human PDE6A, GST-tagged

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Cat.No. : PDE6A-1613H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human PDE6A (31-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Source : Sf9 insect cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 38 nmol/min/mg
Molecular Mass : ~120 kDa
Protein length : 31-end
Purity : >70%
Applications : PDE Assay
Stability : 1 yr at -70oC from date of shipment.
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha [ Homo sapiens ]
Official Symbol : PDE6A
Synonyms : PDE6A; phosphodiesterase 6A, cGMP-specific, rod, alpha; PDEA; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha
Gene ID : 5145
mRNA Refseq : NM_000440
Protein Refseq : NP_000431
MIM : 180071
UniProt ID : P16499
Chromosome Location : 5q31.2-q34
Pathway : Activation of the phototransduction cascade; Inactivation, recovery and regulation of the phototransduction cascade; Signal Transduction
Function : 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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