| Description : |
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
82.8 kDa |
| Protein Length : |
1106 |
| AA Sequence : |
MRLPGAMPALALKGELLLLSLLLLL EPQISQGLVVTPPGPELVLNVSSTF VLTCSGSAPVVWERMSQEPPQEMAK AQDGTFSSVLTLTNLTGLDTGEYFC THNDSRGLETDERKRLYIFVPDPTV GFLPNDAEELFIFLTEITEITIPCR VTDPQLVVTLHEKKGDVALPVPYDH QRGFSGIFEDRSYICKTTIGDREVD SDAYYVYRLQVSSINVSVNAVQTVV RQGENITLMCIVIGNEVVNFEWTYP RKESGRLVEPVTDFLLDMPYHIRSI LHIPSAELEDSGTYTCNVTESVNDH QDEKAINITVVESGYVRLLGEVGTL QFAELHRSRTLQVVFEAYPPPTVLW FKDNRTLGDSSAGEIALSTRNVSET RYVSELTLVRVKVAEAGHYTMRAFH EDAEVQLSFQLQINVPVRVLELSES HPDSGEQTVRCRGRGMPQPNIIWSA CRDLKRCPRELPPTLLGNSSEEESQ LETNVTYWEEEQEFEVVSTLRLQHV DRPLSVRCTLRNAVGQDTQEVIVVP HSLPFKVVVISAILALVVLTIISLI ILIMLWQKKPRYEIRWKVIESVSSD GHEYIYVDPMQLPYDSTWELPRDQL VLGRTLGSGAFGQVVEATAHGLSHS QATMKVAVKMLKSTARSSEKQALMS ELKIMSHLGPHLNVVNLLGACTKGG PIYIITEYCRYGDLVDYLHRNKHTF LQHHSDKRRPPSAELYSNALPVGLP LPSHVSLTGESDGGYMDMSKDESVD YVPMLDMKGDVKYADIESSNYMAPY DNYVPSAPERTCRATLINESPVLSY MDLVGFSYQVANGMEFLASKNCVHR DLAARNVLICEGKLVKICDFGLARD IMRDSNYISKGSTFLPLKWMAPESI FNSLYTTLSDVWSFGILLWEIFTLG GTPYPELPMNEQFYNAIKRGYRMAQ PAHASDEIYEIMQKCWEEKFEIRPP FSQLVLLLERLLGEGYKKKYQQVDE EFLRSDHPAILRSQARLPGFHGLRS PLDTSSVLYTAVQPNEGDNDYIIPL PDPKPEVADEGPLEGSPSLASSTLN EVNTSSTISCDSPLEPQDEPEPEPQ LELQVEPEPELEQLPDSGCPAPRAE AEDSFL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
