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Recombinant Human PDGFRB protein, His-Avi-tagged

Cat.No. : PDGFRB-619H
Product Overview : Human PDGF R beta Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Leu 33-Phe 530.
  • Specification
  • Gene Information
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Description : PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 59 KDa. Due to glycosylation, the protein migrates to 78- 115KDa based on Bis-Tris PAGE result.
Protein length : Leu 33-Phe 530
Endotoxin : Less than 0.2 EU per ug by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : PDGFRB
Official Symbol : PDGFRB
Synonyms : CD140b antigen; CD140b; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; EC 2.7.10; EC 2.7.10.1; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide
Gene ID : 5159
mRNA Refseq : NM_002609.3
Protein Refseq : NP_002600.1
MIM : 173410
UniProt ID : P09619

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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