| Description : |
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
123.8 kDa |
| AA Sequence : |
MRLPGAMPALALKGELLLLSLLLLL EPQISQGLVVTPPGPELVLNVSSTF VLTCSGSAPVVWERMSQEPPQEMAK AQDGTFSSVLTLTNLTGLDTGEYFC THNDSRGLETDERKRLYIFVPDPTV GFLPNDAEELFIFLTEITEITIPCR VTDPQLVVTLHEKKGDVALPVPYDH QRGFFGIFEDRSYICKTTIGDREVD SDAYYVYRLQVSSINVSVNAVQTVV RQGENITLMCIVIGNEVVNFEWTYP RKESGRLVEPVTDFLLDMPYHIRSI LHIPSAELEDSGTYTCNVTESVNDH QDEKAINITVVESGYVRLLGEVGTL QFAELHRSRTLQVVFEAYPPPTVLW FKDNRTLGDSSAGEIALSTRNVSET RYVSELTLVRVKVAEAGHYTMRAFH EDAEVQLSFQLQINVPVRVLELSES HPDSGEQTVRCRGRGMPQPNIIWSA CRDLKRCPRELPPTLLGNSSEEESQ LETNVTYWEEEQEFEVVSTLRLQHV DRPLSVRCTLRNAVGQDTQEVIVVP HSLPFKVVVISAILALVVLTIISLI ILIMLWQKKPRYEIRWKVIESVSSD GHEYIYVDPMQLPYDSTWELPRDQL VLGRTLGSGAFGQVVEATAHGLSHS QATMKVAVKMLKSTARSSEKQALMS ELKIMSHLGPHLNVVNLLGACTKGG PIYIITEYCRYGDLVDYLHRNKHTF LQHHSDKRRPPSAELYSNALPVGLP LPSHVSLTGESDGGYMDMSKDESVD YVPMLDMKGDVKYADIESSNYMAPY DNYVPSAPERTCRATLINESPVLSY MDLVGFSYQVANGMEFLASKNCVHR DLAARNVLICEGKLVKICDFGLARD IMRDSNYISKGSTFLPLKWMAPESI FNSLYTTLSDVWSFGILLWEIFTLG GTPYPELPMNEQFYNAIKRGYRMAQ PAHASDEIYEIMQKCWEEKFEIRPP FSQLVLLLERLLGEGYKKKYQQVDE EFLRSDHPAILRSQARLPGFHGLRS PLDTSSVLYTAVQPNEGDNDYIIPL PDPKPEVADEGPLEGSPSLASSTLN EVNTSSTISCDSPLEPQDEPEPEPQ LELQVEPEPELEQLPDSGCPAPRAE AEDSFLTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
