| Description : |
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85.2 kDa |
| AA Sequence : |
MTHEEHHAAKTLGIGKAIAVLTSGG DAQGMNAAVRAVVRVGIFTGARVFF VHEGYQGLVDGGDHIKEATWESVSM MLQLGGTVIGSARCKDFREREGRLR AAYNLVKRGITNLCVIGGDGSLTGA DTFRSEWSDLLSDLQKAGKITDEEA TKSSYLNIVGLVGSIDNDFCGTDMT IGTDSALHRIMEIVDAITTTAQSHQ RTFVLEVMGRHCGYLALVTSLSCGA DWVFIPECPPDDDWEEHLCRRLSET RTRGSRLNIIIVAEGAIDKNGKPIT SEDIKNLVVKRLGYDTRVTVLGHVQ RGGTPSAFDRILGSRMGVEAVMALL EGTPDTPACVVSLSGNQAVRLPLME CVQVTKDVTKAMDEKKFDEALKLRG RSFMNNWEVYKLLAHVRPPVSKSGS HTVAVMNVGAPAAGMNAAVRSTVRI GLIQGNRVLVVHDGFEGLAKGQIEE AGWSYVGGWTGQGGSKLGTKRTLPK KSFEQISANITKFNIQGLVIIGGFE AYTGGLELMEGRKQFDELCIPFVVI PATVSNNVPGSDFSVGADTALNTIC TTCDRIKQSAAGTKRRVFIIETMGG YCGYLATMAGLAAGADAAYIFEEPF TIRDLQANVEHLVQKMKTTVKRGLV LRNEKCNENYTTDFIFNLYSEEGKG IFDSRKNVLGHMQQGGSPTPFDRNF ATKMGAKAMNWMSGKIKESYRNGRI FANTPDSGCVLGMRKRALVFQPVAE LKDQTDFEHRIPKEQWWLKLRPILK ILAKYEIDLDTSDHAHLEHITRKRS GEAAVTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
