Recombinant Human PHD finger protein 11, His-tagged

• Cat.No.: PHF11-351H
• Product Overview: PHF11, 1-331aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-331 a.a.
• Description: PHD finger protein 11, also known as PHF11, is a regulator of TH1-type cytokine gene expression. The reduction in PHF11 expression seen with an AD-associated genotype could contribute to the strong TH2 responses that characterize many allergic individuals. PHF11 are associated with increased total serum IgE levels, asthma, and severe atopic dermatitis (AD) in children. Although PHF11 includes a plant homeodomain, a motif often found in transcriptional regulators, the function of PHF11 has not been investigated. Recombinant human PHF11 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Molecular Mass: 39.7 kDa (351aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PHF11 PHD finger protein 11 [ Homo sapiens ]
• Official Symbol: PHF11
• Synonyms: PHF11; PHD finger protein 11; BCAP; IgE responsiveness (atopic); IGER; NY REN 34; NY-REN-34 antigen; renal carcinoma antigen NY-REN-34; BRCA1 C-terminus-associated protein; APY; IGEL; IGHER; NYREN34; NY-REN-34; RP11-185C18.3
• Gene ID: 51131
• mRNA Refseq: NM_001040443
• Protein Refseq: NP_001035533
• MIM: 607796
• UniProt ID: Q9UIL8
• Chromosome Location: 13q14.11
• Function: metal ion binding; zinc ion binding