Recombinant Human PHGDH Protein, His-tagged

• Cat.No.: PHGDH-477H
• Product Overview: Recombinant Human PHGDH fused with His tag at N-terminal was expressed in Sf9 cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Protein Length: 1-533 aa
• Description: THis gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in tHis gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.
• Form: 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 56.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PHGDH phosphoglycerate dehydrogenase [ Homo sapiens ]
• Official Symbol: PHGDH
• Synonyms: PHGDH; phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; PDG; PGDH; SERA; 3-phosphoglycerate dehydrogenase; PGD; PGAD; 3PGDH; 3-PGDH; MGC3017
• Gene ID: 26227
• mRNA Refseq: NM_006623
• Protein Refseq: NP_006614
• MIM: 606879
• UniProt ID: O43175