Recombinant Human PHLDA3 protein, Myc/DDK-tagged

• Cat.No.: PHLDA3-1692H
• Product Overview: Recombinant Human PHLDA3 protein, fused with Myc/DDK-tagged, was expressed in HEK293T and captured through anti-DDK affinity column followed by conventional chromatography steps.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 13.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Concentration: >50 μg/mL as determined by microplate BCA method.

Gene Information

• Gene Name: PHLDA3
• Official Symbol: PHLDA3
• Synonyms: TIH1
• Gene ID: 23612
• mRNA Refseq: NM_012396.5
• Protein Refseq: NP_036528.1
• MIM: 607054
• UniProt ID: Q9Y5J5