Recombinant Human PHLDA3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PHLDA3-2129H
• Product Overview: PHLDA3 MS Standard C13 and N15-labeled recombinant protein (NP_036528) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
• Molecular Mass: 13.9 kDa
• AA Sequence: MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVSTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PHLDA3 pleckstrin homology like domain family A member 3 [ Homo sapiens (human) ]
• Official Symbol: PHLDA3
• Synonyms: PHLDA3; pleckstrin homology-like domain, family A, member 3; pleckstrin homology-like domain family A member 3; pleckstrin homology like domain; family A; member 2; TIH1; TDAG51/Ipl homolog 1; pleckstrin homology-like domain, family A, member 2
• Gene ID: 23612
• mRNA Refseq: NM_012396
• Protein Refseq: NP_036528
• MIM: 607054
• UniProt ID: Q9Y5J5