Active Recombinant Human PI4KA protein, GST-tagged
Cat.No. : | PI4KA-161H |
Product Overview : | Recombinant Human PI4KA fused with an N-terminal GST tag was expressed in Insect cells. |
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Description : | PI4KA encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by PI4KA gene is a type III enzyme that is not inhibited by adenosine. PI4KA is highly expressed in placenta and brain. PI4KA is associated with the membranes of Golgi vesicles and vacuoles. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 70 nmol/min/mg |
Molecular Mass : | ~120 kDa |
Purity : | >70% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05μg/μl |
Publication : |
PI-273, a substrate-competitive, specific small molecule inhibitor of PI4KIIα, inhibits the growth of breast cancer cells (2017)
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Gene Name : | PI4KA phosphatidylinositol 4-kinase, catalytic, alpha [ Homo sapiens ] |
Official Symbol : | PI4KA |
Synonyms : | PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha; PIK4CA; phosphatidylinositol 4-kinase alpha; PI4K ALPHA; pi4K230; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase, type III, alpha; PI4K-ALPHA; FLJ16556; |
Gene ID : | 5297 |
mRNA Refseq : | NM_002650 |
Protein Refseq : | NP_002641 |
MIM : | 600286 |
UniProt ID : | P42356 |
Chromosome Location : | 22q11.21 |
Pathway : | 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Inositol phosphate metabolism, PI=> |
Function : | 1-phosphatidylinositol 4-kinase activity; ATP binding; nucleotide binding; phosphatidylinositol 3-kinase activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
PI4KA-4099R | Recombinant Rat PI4KA Protein, His (Fc)-Avi-tagged | +Inquiry |
PI4KA-4905H | Recombinant Human PI4KA Protein (Met1-Tyr300), N-GST tagged | +Inquiry |
PI4KA-30331TH | Recombinant Human PI4KA | +Inquiry |
PI4KA-1701H | Recombinant Human PI4KA protein, His-GST-tagged | +Inquiry |
PI4KA-117H | Recombinant Human PI4KA, GST-tagged | +Inquiry |
◆ Lysates | ||
PI4KA-3207HCL | Recombinant Human PI4KA 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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