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Active Recombinant Human PI4KA protein, GST-tagged

Cat.No. : PI4KA-161H
Product Overview : Recombinant Human PI4KA fused with an N-terminal GST tag was expressed in Insect cells.
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Description : PI4KA encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by PI4KA gene is a type III enzyme that is not inhibited by adenosine. PI4KA is highly expressed in placenta and brain. PI4KA is associated with the membranes of Golgi vesicles and vacuoles.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 70 nmol/min/mg
Molecular Mass : ~120 kDa
Purity : >70%
Applications : Kinase Assay
Stability : 1 year at -70 centigrade from the date of shipment
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05μg/μl
Publication :
PI-273, a substrate-competitive, specific small molecule inhibitor of PI4KIIα, inhibits the growth of breast cancer cells (2017)
Gene Name : PI4KA phosphatidylinositol 4-kinase, catalytic, alpha [ Homo sapiens ]
Official Symbol : PI4KA
Synonyms : PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha; PIK4CA; phosphatidylinositol 4-kinase alpha; PI4K ALPHA; pi4K230; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase, type III, alpha; PI4K-ALPHA; FLJ16556;
Gene ID : 5297
mRNA Refseq : NM_002650
Protein Refseq : NP_002641
MIM : 600286
UniProt ID : P42356
Chromosome Location : 22q11.21
Pathway : 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Inositol phosphate metabolism, PI=>
Function : 1-phosphatidylinositol 4-kinase activity; ATP binding; nucleotide binding; phosphatidylinositol 3-kinase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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