Active Recombinant Human PIK3C2G protein, GST-tagged

• Cat.No.: PIK3C2G-165H
• Product Overview: Recombinant Human PIK3C2G(468-1203 aa) fused with an N-terminal GST tag was expressed in Insect cells.

Specification

• Description: PIK3C2G belongs to the phosphoinositide 3-kinase (PI3K) family which plays main roles in signaling pathways and involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions and the N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 4400 nmol/min/mg
• Molecular Mass: 110 kDa
• Purity: >80%
• Applications: Kinase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide [ Homo sapiens ]
• Official Symbol: PIK3C2G
• Synonyms: PIK3C2G; phosphoinositide-3-kinase, class 2, gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; PTDINS-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma; phosphoinositide 3-kinase-C2-gamma; phosphatidylinositol 3-kinase C2 domain-containing gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; PI3K-C2GAMMA; MGC163149
• Gene ID: 5288
• mRNA Refseq: NM_004570
• Protein Refseq: NP_004561
• MIM: 609001
• UniProt ID: O75747
• Chromosome Location: 12p12
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Insulin Signaling, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Phosphatidylinositol signaling system, organism-specific biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; binding; nucleotide binding; phosphatidylinositol binding; phosphatidylinositol phosphate kinase activity