Recombinant Human PIM3 Protein (L2-L326), GST tagged

• Cat.No.: PIM3-0924H
• Product Overview: Recombinant Human GST-TEV-GG-PIM3(L2-L326 end) Protein was expressed in Insect cell.

Specification

• Description: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: L2-L326
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: PIM3 pim-3 oncogene [ Homo sapiens (human) ]
• Official Symbol: PIM3
• Synonyms: PIM3; pim-3 oncogene; serine/threonine-protein kinase pim-3; serine/threonine kinase Pim-3; pim-3
• Gene ID: 415116
• mRNA Refseq: NM_001001852
• Protein Refseq: NP_001001852
• MIM: 610580
• UniProt ID: Q86V86