Recombinant Human PLEKHM2 Protein, MYC/DDK-tagged PLEKHM2-2101H

Recombinant Human PLEKHM2 Protein, MYC/DDK-tagged

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Recombinant Human PLEKHM2 Protein, MYC/DDK-tagged

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Cat.No. : PLEKHM2-2101H
Product Overview : Recombinant human PLEKHM2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 112.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 [ Homo sapiens ]
Official Symbol : PLEKHM2
Synonyms : SKIP; SKIP
Gene ID : 23207
mRNA Refseq : NM_015164
Protein Refseq : NP_055979
MIM : 609613
UniProt ID : Q8IWE5

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