Recombinant Human PLEKHM2 Protein, MYC/DDK-tagged


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Recombinant Human PLEKHM2 Protein, MYC/DDK-tagged

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Cat.No. : PLEKHM2-2101H
Product Overview : Recombinant human PLEKHM2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Source : HEK293
Species : Human
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 112.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 [ Homo sapiens ]
Official Symbol : PLEKHM2
Synonyms : SKIP; SKIP
Gene ID : 23207
mRNA Refseq : NM_015164
Protein Refseq : NP_055979
MIM : 609613
UniProt ID : Q8IWE5
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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