Recombinant Human POT1 Protein, Flag-tagged

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Recombinant Human POT1 Protein, Flag-tagged

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Cat.No. : POT1-2788H
Product Overview : Recombinant Human POT1 Protein is produced by HEK293T expression system. This protein is fused with a Flag tag.
Description : This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Source : HEK293
Species : Human
Tag : Flag
Form : PBS buffer
Molecular Mass : 71 kDa
AA Sequence : MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS KYFNFTTEDH KMVEALRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN QHSDVICQSE PDDSFPSSGS VSLYEVERCQ QLSATILTDH QYLERTPLCA ILKQKAPQQY RIRAKLRSYK PRRLFQSVKL HCPKCHLLQE VPHEGDLDII FQDGATKTPV VKLQNTSLYD SKIWTTKNQK GRKVAVHFVK NNGILPLSNE CLLLIEGGTL SEICKLSNKF NSVIPVRSGH EDLELLDLSA PFLIQGTIHH YGCKQCSSLR SIQNLNSLVD KTSWIPSSVA EALGIVPLQY VFVMTFTLDD GTGVLEAYLM DSDKFFQIPA SEVLMDDDLQ KSVDMIMDMF CPPGIKIDAY PWLECFIKSY NVTNGTDNQI CYQIFDTTVA EDVITRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Notes : Avoid repeated freeze-thaw cycles.
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at –80 centigrade.
Gene Name : POT1 protection of telomeres 1 homolog (S. pombe) [ Homo sapiens ]
Official Symbol : POT1
Synonyms : POT1; DKFZp586D211; hPot1; POT1-like telomere end-binding protein; HPOT1;
Gene ID : 25913
mRNA Refseq : NM_001042594
Protein Refseq : NP_001036059
MIM : 606478
UniProt ID : Q9NUX5

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