Recombinant Human PPARGC1A protein, GST-tagged

• Cat.No.: PPARGC1A-8291H
• Product Overview: Recombinant Human PPARGC1A(689 a.a. - 798 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 37.84 kDa
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens ]
• Official Symbol: PPARGC1A
• Synonyms: PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; PGC-1-alpha; L-PGC-1alpha; PPARGC-1-alpha; ligand effect modulator-6; PPAR gamma coactivator variant form; LEM6; PGC-1v; PPARGC1; PGC-1(alpha)
• Gene ID: 10891
• mRNA Refseq: NM_013261
• Protein Refseq: NP_037393
• MIM: 604517
• UniProt ID: Q9UBK2
• Chromosome Location: 4p15.1
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem
• Function: DNA binding; RNA binding; RNA polymerase II transcription cofactor activity; androgen receptor binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; transcription coactivator activity; transcription factor binding