Recombinant Mouse Ppargc1a protein, His-tagged

• Cat.No.: Ppargc1a-8492M
• Product Overview: Recombinant Mouse Ppargc1a(Cys577-Asn766) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Mouse
• Tag: His
• Molecular Mass: 24.7 kDa
• AA Sequence: MGHHHHHHSGSEF- CSRS PYSRSRSRSP GSRSSSRSCY YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC GRKQFFKSNY ADLDTN
• Purity: Purity is > 95%.
• Applications: SDS-PAGE, WB, ELISA, IP

Gene Information

• Gene Name: Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus ]
• Official Symbol: Ppargc1a
• Synonyms: PPARGC1A; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; Pgc-1alphaa; PPARGC-1-alpha; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPAR gamma coactivator variant form; Pgc1; PGC-1; Pgco1; PGC-1v; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; ENSMUSG00000079510
• Gene ID: 19017
• mRNA Refseq: NM_008904
• Protein Refseq: NP_032930
• UniProt ID: O70343
• Chromosome Location: 5; 5 C1
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Huntingtons disease, organism-specific biosystem
• Function: DNA binding; RNA binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleic acid binding; nucleotide binding; protein binding; receptor activity; transcription coactivator activity; transcription coactivator activity; transcription factor binding