"Ppargc1a" Related Products

Recombinant Mouse Ppargc1a protein, His-tagged

Cat.No.: Ppargc1a-8492M
Product Overview: Recombinant Mouse Ppargc1a(Cys577-Asn766) fused with His tag at N-terminal was expressed in E. coli.
Description: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants.
Source: E. coli
Species: Mouse
Tag: His
Molecular Mass: 24.7 kDa
AA Sequence: MGHHHHHHSGSEF- CSRS PYSRSRSRSP GSRSSSRSCY YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC GRKQFFKSNY ADLDTN
Purity: Purity is > 95%.
Applications: SDS-PAGE, WB, ELISA, IP
Gene Name: Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus ]
Official Symbol: Ppargc1a
Synonyms: PPARGC1A; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; Pgc-1alphaa; PPARGC-1-alpha; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPAR gamma coactivator variant form; Pgc1; PGC-1; Pgco1; PGC-1v; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; ENSMUSG00000079510;
Gene ID: 19017
mRNA Refseq: NM_008904
Protein Refseq: NP_032930
MIM:
UniProt ID: O70343
Chromosome Location: 5; 5 C1
Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Huntingtons disease, organism-specific biosystem;
Function: DNA binding; RNA binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleic acid binding; nucleotide binding; protein binding; receptor activity; transcription coactivator activity; transcription coactivator activity; transcription factor binding;

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