Recombinant Human PPM1K, His-tagged

• Cat.No.: PPM1K-174H
• Product Overview: Recombinant Human Protein Phosphatase 1K Mitochondrial/PPM1K is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asp30-Ala372) of Human PPM1K fused with a polyhistidine tag at the C-terminus.

Specification

• Description: Protein Phosphatase 1K Mitochondrial (PPM1K) is a member of the PP2C family. PPM1K localizes to the cell mitochondrion matrix and contains one PP2C-like domain. PPM1K has metal ion binding and protein serine/threonine phosphatase activity. One subunit of PPM1K can bind one magnesium or manganese ion. PPM1K regulates the mitochondrial permeability transition pore and it is essential for cellular survival and development.
• Source: HEK293
• Species: Human
• Tag: His
• AA Sequence: DDRRVTPTCHSSTSEPRCSRFDPDGSGSPATWDNFGIWDNRIDEPILLPPSIKYGKPIPK61ISL EKVGCASQIGKRKENEDRFDFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDL121LPKEK NLETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRDGIELVVASVGDS181RAILCRK GKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDL241KTSGVIAEP ETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQ31AIQYGTEDNST AVVVPFGAWGKYKNSEINFSFSRSFASSGRWAVDHHHHHH
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg).
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Protein length: 30-372 a.a.

Gene Information

• Gene Name: PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K [ Homo sapiens ]
• Official Symbol: PPM1K
• Synonyms: PPM1K; protein phosphatase, Mg2+/Mn2+ dependent, 1K; protein phosphatase 1K (PP2C domain containing); protein phosphatase 1K, mitochondrial; BDP; branched chain α ketoacid dehydrogenase phosphatase; DKFZp761G058; hPTMP; PP2C type mitochondrial phosphoprotein phosphatase; PP2Ckappa; PP2Cm; protein phosphatase 2C kappa; PP2C-kappa; PP2C-like protein; PP2C-like mitochondrial protein; PP2C type mitochondrial phosphatase; protein phosphatase 2C isoform kappa; PP2C domain-containing protein phosphatase 1K; PP2C-type mitochondrial phosphoprotein phosphatase; branched-chain & #945; -ketoacid dehydrogenase phosphatase; PTMP; UG0882E07; DKFZp667B084
• Gene ID: 152926
• mRNA Refseq: NM_152542
• Protein Refseq: NP_689755
• MIM: 611065
• UniProt ID: Q8N3J5
• Chromosome Location: 4q22.1
• Function: hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity