| Description : |
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.4 kDa |
| AA Sequence : |
MASHVDLLTELQLLEKVPTLERLRA AQKRRAQQLKKWAQYEQDLQHRKRK HERKRSTGGRRKKVSFEASVALLEA SLRNDAEEVRYFLKNKVSPDLCNED GLTALHQCCIDNFEEIVKLLLSHGA NVNAKDNELWTPLHAAATCGHINLV KILVQYGADLLAVNSDGNMPYDLCE DEPTLDVIETCMAYQGITQEKINEM RVAPEQQMIADIHCMIAAGQDLDWI DAQGATLLHIAGANGYLRAAELLLD HGVRVDVKDWDGWEPLHAAAFWGQM QMAELLVSHGASLSARTSMDEMPID LCEEEEFKVLLLELKHKHDVIMKSQ LRHKSSLSRRTSSAGSRGKVVRRAS LSDRTNLYRKEYEGEAILWQRSAAE DQRTSTYNGDIRETRTDQENKDPNP RLEKPVLLSEFPTKIPRGELDMPVE NGLRAPVSAYQYALANGDVWKVHEV PDYSMAYGNPGVADATPPWSSYKEQ SPQTLLELKRQRAAAKLLSHPFLST HLGSSMARTGESSSEGKAPLIGGRT SPYSSNGTSVYYTVTSGDPPLLKFK APIEEMEEKVHGCCRISTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
