Recombinant Human PRDM16 protein, MYC/DDK-tagged

• Cat.No.: PRDM16-8327H
• Product Overview: Recombinant Human PRDM16 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 140.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PRDM16 PR domain containing 16 [ Homo sapiens ]
• Official Symbol: PRDM16
• Synonyms: PRDM16; PR domain containing 16; PR domain zinc finger protein 16; KIAA1675; MDS1/EVI1 like; MEL1; MGC166915; PFM13; transcription factor MEL1; MDS1/EVI1-like gene 1
• Gene ID: 63976
• mRNA Refseq: NM_022114
• Protein Refseq: NP_071397
• MIM: 605557
• UniProt ID: Q9HAZ2
• Chromosome Location: 1p36.23-p33
• Function: SMAD binding; metal ion binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; zinc ion binding