| Cat.No.: | PRKAA1-2953H |
| Product Overview: | Recombinant Human PRKAA1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
| Description: | The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Source: | HEK293 |
| Species: | Human |
| Tag : | MYC/DDK |
| Form: | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass: | 63.8 kDa |
| Purity: | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration: | >50 ug/mL as determined by microplate BCA method |
| Gene Name: | PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit [ Homo sapiens ] |
| Official Symbol: | PRKAA1 |
| Synonyms: | AMPK; AMPKa1 |
| Gene ID: | 5562 |
| mRNA Refseq: | NM_006251 |
| Protein Refseq: | NP_006242 |
| MIM: | 602739 |
| UniProt ID: | Q13131 |
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