| Description : |
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
41.4 kDa |
| AA Sequence : |
MSSPSLSDLGKREPAAAADERGTQQ RRACANATWNSIHNGVIAVFQRKGL PDQELFSLNEGVRQLLKTELGSFFT EYLQNQLLTKGMVILRDKIRFYEGQ KLLDSLAETWDFFFSDVLPMLQAIF YPVQGKEPSVRQLALLHFRNAITLS VKLEDALARAHARVPPAIVQMLLVL QGVHESRGVTEDYLRLETLVQKVVS PYLGTYGLHSSEGPFTHSCILEKRL LRRSRSGDVLAKNPVVRSKSYNTPL LNPVQEHEAEGAAAGGTSIRRHSVS EMTSCPEPQGFSDPPGQGPTGTFRS SPAPHSGPCPSRLYPTTQPPEQGLD PTRSSLPRSSPENLVDQILESVDSD SEGIFIDFGRGRGSGMSDLEGSGGR QSVVTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
