Recombinant Human PSMD3

• Cat.No.: PSMD3-30428TH
• Product Overview: Recombinant full length Human Proteasome 19S S3 with a N terminal proprietary tag; Predicted MWt 84.74 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 534 amino acids
• Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.
• Molecular Weight: 84.740kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMK EEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEH VKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQ GFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTP LLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQ NRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTA TLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPE QANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQ HTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLM PYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRL RHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIV AKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQ RISFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQD LEFAKEMAEDDDDSFP
• Sequence Similarities: Belongs to the proteasome subunit S3 family.Contains 1 PCI domain.

Gene Information

• Gene Name: PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [ Homo sapiens ]
• Official Symbol: PSMD3
• Synonyms: PSMD3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; tissue specific transplantation antigen 2 , TSTA2; 26S proteasome non-ATPase regulatory subunit 3; P58; Rpn3; S3
• Gene ID: 5709
• mRNA Refseq: NM_002809
• Protein Refseq: NP_002800
• Uniprot ID: O43242
• Chromosome Location: 17q21.2
• Pathway: APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem
• Function: binding; enzyme regulator activity