Recombinant Human PTHLH protein, His/S-tagged

• Cat.No.: PTHLH-113H
• Product Overview: Recombinant Human PTHLH protein (Ala37-His177), fused to His/S-tag at N-terminus, was expressed in E.coli.

Specification

• Description: The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.
• Source: E.coli
• Species: Human
• Tag: His/S
• Form: Supplied as lyophilized form in PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and preservative.
• Molecular Mass: 21.7kDa
• Protein length: 193
• AA Sequence: MHHHHHHSSGLVPRGSGMKETAAAK FERQHMDSPDLGTDDDDKAMADIGS EFAVSEHQLLHDKGKSIQDLRRRFF LHHLIAEIHTAEIRATSEVSPNSKP SPNTKNHPVRFGSDDEGRYLTQETN KVETYKEQPLKTPGKKKKGKPGKRK EQEKKKRRTRSAWLDSGVTGSGLEG DHLSDTSTTSLELDSRRH
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in sterile PBS, pH7.2 - pH7.4.

Gene Information

• Gene Name: PTHLH
• Official Symbol: PTHLH
• Synonyms: HHM; PLP; BDE2; PTHR; PTHRP
• Gene ID: 5744
• mRNA Refseq: NM_198965.2
• Protein Refseq: NP_945316.1
• MIM: 168470
• UniProt ID: P12272