Recombinant Human PTPN12 Protein, MYC/DDK-tagged
Cat.No. : | PTPN12-3135H |
Product Overview : | Recombinant Human PTPN12 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
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Description : | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 87.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ] |
Official Symbol : | PTPN12 |
Synonyms : | PTP-PEST; PTPG1 |
Gene ID : | 5782 |
mRNA Refseq : | NM_001131008 |
Protein Refseq : | NP_001124480 |
MIM : | 600079 |
UniProt ID : | Q05209 |
Products Types
◆ Recombinant Protein | ||
PTPN12-7276M | Recombinant Mouse PTPN12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ptpn12-2002M | Recombinant Mouse Ptpn12 Protein, His&GST-tagged | +Inquiry |
Ptpn12-5236M | Recombinant Mouse Ptpn12 Protein, Myc/DDK-tagged | +Inquiry |
PTPN12-13676M | Recombinant Mouse PTPN12 Protein | +Inquiry |
PTPN12-10938Z | Recombinant Zebrafish PTPN12 | +Inquiry |
◆ Lysates | ||
PTPN12-002HCL | Recombinant Human PTPN12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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