Recombinant Human PTPN12 Protein, MYC/DDK-tagged
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Cat.No. : | PTPN12-3135H |
Product Overview : | Recombinant Human PTPN12 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293. |
Description : | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 87.9 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | PTPN12 protein tyrosine phosphatase, non-receptor type 12 [ Homo sapiens ] |
Official Symbol : | PTPN12 |
Synonyms : | PTP-PEST; PTPG1 |
Gene ID : | 5782 |
mRNA Refseq : | NM_001131008 |
Protein Refseq : | NP_001124480 |
MIM : | 600079 |
UniProt ID : | Q05209 |
◆ Recombinant Protein
Ptpn12-5236M | Recombinant Mouse Ptpn12 Protein, Myc/DDK-tagged | +Inquiry |
PTPN12-411H | Recombinant Human PTPN12, Gly & Pro tagged | +Inquiry |
PTPN12-10938Z | Recombinant Zebrafish PTPN12 | +Inquiry |
PTPN12-8096H | Recombinant Human PTPN12 protein, His & T7-tagged | +Inquiry |
PTPN12-13676M | Recombinant Mouse PTPN12 Protein | +Inquiry |
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◆ Lysates
PTPN12-002HCL | Recombinant Human PTPN12 cell lysate | +Inquiry |
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PTPN1PTPN11PTPN12PTPN13PTPN14PTPN2PTPN4PTPN6PTPN7PTPN9PTPN22PTPN5PTPN23PTPN20BPTPN3PTPN21PTPN18Ptpn20PTPN20A
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