Recombinant Human PTPN14, GST-tagged

• Cat.No.: PTPN14-454H
• Product Overview: Recombinant Human Catalytic domain, (a.a. 817-1188), with N-terminal GST tag expressed in anE.coliexpression system. MW= 61 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 817-1188 a.a.
• Description: Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.
• Purity: >90% by SDS-PAGE.
• Application: Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
• Stability: >12 months at –80°C.

Gene Information

• Gene Name: PTPN14 protein tyrosine phosphatase, non-receptor type 14 [ Homo sapiens ]
• Synonyms: PTPN14; protein tyrosine phosphatase, non-receptor type 14; PEZ; PTP36; MGC126803; cytoskeletal-associated protein tyrosine phosphatase; EC 3.1.3.48; Tyrosine-protein phosphatase non-receptor type 14; Protein-tyrosine phosphatase pez
• Gene ID: 5784
• mRNA Refseq: NM_005401
• Protein Refseq: NP_005392
• MIM: 603155
• UniProt ID: Q15678
• Chromosome Location: 1q32.2
• Function: binding; hydrolase activity; protein tyrosine phosphatase activity