| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
50.3 kDa |
| AA Sequence : |
MSRSLDSARSFLERLEARGGREGAV LAGEFSDIQACSAAWKADGVCSTVA GSRPENVRKNRYKDVLPYDQTRVIL SLLQEEGHSDYINGNFIRGVDGSLA YIATQGPLPHTLLDFWRLVWEFGVK VILMACREIENGRKRCERYWAQEQE PLQTGLFCITLIKEKWLNEDIMLRT LKVTFQKESRSVYQLQYMSWPDRGV PSSPDHMLAMVEEARRLQGSGPEPL CVHCSAGCGRTGVLCTVDYVRQLLL TQMIPPDFSLFDVVLKMRKQRPAAV QTEEQYRFLYHTVAQMFCSTLQNAS PHYQNIKENCAPLYDDALFLRTPQA LLAIPRPPGGVLRSISVPGSPGHAM ADTYAVVQKRGAPAGAGSGTQTGTG TGTGARSAEEAPLYSKVTPRAQRPG AHAEDARGTLPGRVPADQSPAGSGA YEDVAGGAQTGGLGFNLRIGRPKGP RDPPAEWTRVTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
