| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
168.4 kDa |
| AA Sequence : |
MAPTWGPGMVSVVGPMGLLVVLLVG GCAAEEPPRFIKEPKDQIGVSGGVA SFVCQATGDPKPRVTWNKKGKKVNS QRFETIEFDESAGAVLRIQPLRTPR DENVYECVAQNSVGEITVHAKLTVL REDQLPSGFPNIDMGPQLKVVERTR TATMLCAASGNPDPEITWFKDFLPV DPSASNGRIKQLRSGALQIESSEET DQGKYECVATNSAGVRYSSPANLYV RVRRVAPRFSILPMSHEIMPGGNVN ITCVAVGSPMPYVKWMQGAEDLTPE DDMPVGRNVLELTDVKDSANYTCVA MSSLGVIEAVAQITVKSLPKAPGTP MVTENTATSITITWDSGNPDPVSYY VIEYKSKSQDGPYQIKEDITTTRYS IGGLSPNSEYEIWVSAVNSIGQGPP SESVVTRTGEQAPASAPRNVQARML SATTMIVQWEEPVEPNGLIRGYRVY YTMEPEHPVGNWQKHNVDDSLLTTV GSLLEDETYTVRVLAFTSVGDGPLS DPIQVKTQQGVPGQPMNLRAEARSE TSITLSWSPPRQESIIKYELLFREG DHGREVGRTFDPTTSYVVEDLKPNT EYAFRLAARSPQGLGAFTPVVRQRT LQSISPKNFKVKMIMKTSVLLSWEF PDNYNSPTPYKIQYNGLTLDVDGRT TKKLITHLKPHTFYNFVLTNRGSSL GGLQQTVTAWTAFNLLNGKPSVAPK PDADGFIMVYLPDGQSPVPVQSYFI VMVPLRKSRGGQFLTPLGSPEDMDL EELIQDISRLQRRSLRHSRQLEVPR PYIAARFSVLPPTFHPGDQKQYGGF DNRGLEPGHRYVLFVLAVLQKSEPT FAASPFSDPFQLDNPDPQPIVDGEE GLIWVIGPVLAVVFIICIVIAILLY KNKPDSKRKDSEPRTKCLLNNADLA PHHPKDPVEMRRINFQTPGMLSHPP IPIADMAEHTERLKANDSLKLSQEY ESIDPGQQFTWEHSNLEVNKPKNRY ANVIAYDHSRVILQPIEGIMGSDYI NANYVDGYRRQNAYIATQGPLPETF GDFWRMVWEQRSATIVMMTRLEEKS RIKCDQYWPNRGTETYGFIQVTLLD TIELATFCVRTFSLHKNGSSEKREV RQFQFTAWPDHGVPEYPTPFLAFLR RVKTCNPPDAGPIVVHCSAGVGRTG CFIVIDAMLERIKPEKTVDVYGHVT LMRSQRNYMVQTEDQYSFIHEALLE AVGCGNTEVPARSLYAYIQKLAQVE PGEHVTGMELEFKRLANSKAHTSRF ISANLPCNKFKNRLVNIMPYESTRV CLQPIRGVEGSDYINASFIDGYRQQ KAYIATQGPLAETTEDFWRMLWENN STIVVMLTKLREMGREKCHQYWPAE RSARYQYFVVDPMAEYNMPQYILRE FKVTDARDGQSRTVRQFQFTDWPEQ GVPKSGEGFIDFIGQVHKTKEQFGQ DGPISVHCSAGVGRTGVFITLSIVL ERMRYEGVVDIFQTVKMLRTQRPAM VQTEDEYQFCYQAALEYLGSFDHYA TSGPTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
