Recombinant Human PTPRS Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human PTPRS Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : PTPRS-2766H
Product Overview : PTPRS MS Standard C13 and N15-labeled recombinant protein (NP_570925) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 166.1 kDa
AA Sequence : MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRELRE VRRVAPRFSI LPMSHEIMPG GNVNITCVAV GSPMPYVKWM QGAEDLTPED DMPVGRNVLE LTDVKDSANY TCVAMSSLGV IEAVAQITVK SLPKAPGTPM VTENTATSIT ITWDSGNPDP VSYYVIEYKS KSQDGPYQIK EDITTTRYSI GGLSPNSEYE IWVSAVNSIG QGPPSESVVT RTGEQAPASA PRNVQARMLS ATTMIVQWEE PVEPNGLIRG YRVYYTMEPE HPVGNWQKHN VDDSLLTTVG SLLEDETYTV RVLAFTSVGD GPLSDPIQVK TQQGVPGQPM NLRAEARSET SITLSWSPPR QESIIKYELL FREGDHGREV GRTFDPTTSY VVEDLKPNTE YAFRLAARSP QGLGAFTPVV RQRTLQSISP KNFKVKMIMK TSVLLSWEFP DNYNSPTPYK IQYNGLTLDV DGRTTKKLIT HLKPHTFYNF VLTNRGSSLG GLQQTVTAWT AFNLLNGKPS VAPKPDADGF IMVYLPDGQS PVPVQSYFIV MVPLRKSRGG QFLTPLGSPE DMDLEELIQD ISRLQRRSLR HSRQLEVPRP YIAARFSVLP PTFHPGDQKQ YGGFDNRGLE PGHRYVLFVL AVLQKSEPTF AASPFSDPFQ LDNPDPQPIV DGEEGLIWVI GPVLAVVFII CIVIAILLYK NKPDSKRKDS EPRTKCLLNN ADLAPHHPKD PVEMRRINFQ TPGMLSHPPI PIADMAEHTE RLKANDSLKL SQEYESIDPG QQFTWEHSNL EVNKPKNRYA NVIAYDHSRV ILQPIEGIMG SDYINANYVD GYRCQNAYIA TQGPLPETFG DFWRMVWEQR SATIVMMTRL EEKSRIKCDQ YWPNRGTETY GFIQVTLLDT IELATFCVRT FSLHKNGSSE KREVRQFQFT AWPDHGVPEY PTPFLAFLRR VKTCNPPDAG PIVVHCSAGV GRTGCFIVID AMLERIKPEK TVDVYGHVTL MRSQRNYMVQ TEDQYSFIHE ALLEAVGCGN TEVPARSLYA YIQKLAQVEP GEHVTGMELE FKRLANSKAH TSRFISANLP CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFIDG YRQQKAYIAT QGPLAETTED FWRMLWENNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ YFVVDPMAEY NMPQYILREF KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV HKTKEQFGQD GPISVHCSAG VGRTGVFITL SIVLERMRYE GVVDIFQTVK MLRTQRPAMV QTEDEYQFCY QAALEYLGSF DHYATSGPTR TRRLEQKLIS EEDLAANDIL DYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : PTPRS protein tyrosine phosphatase receptor type S [ Homo sapiens (human) ]
Official Symbol : PTPRS
Synonyms : PTPRS; protein tyrosine phosphatase, receptor type, S; receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; protein tyrosine phosphatase, receptor type, sigma; PTPSIGMA;
Gene ID : 5802
mRNA Refseq : NM_130855
Protein Refseq : NP_570925
MIM : 601576
UniProt ID : Q13332

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